University of Nevada, Las Vegas; Center for Academic Enrichment and Outreach
Various diseases are caused by defective genes or mutations within the DNA. These mutations can cause cancer cells, which are usually treated through chemotherapy and radiation. However, these methods have not completely effective towards cancer stem cells, a group of cancer cells that possess stem cell properties and are capable of initiating cancer. In order to discover new methods of targeting these specific cells, technology for genome engineering will enable researchers to further study genetic requirements within these cells. The method of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 will help cleave and alter genomic sequences to potentially correct the genomic mutations caused by the cancer stem cell. Using the technology of CRISPR-Cas9, studies of these cells and growth requirements can help discover new ways to target the cancer stem cell as a new method of therapy.
Cancer Cells; mutations; CRISPR-Cas9
Cells | Medicine and Health Sciences
Pham, E. K.,
Regulation of Cancer Stem Cells by Protein Post-Translational Modifications.
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