Location
University of Nevada Las Vegas, Student Union Ball Room
Start Date
6-8-2008 9:00 AM
End Date
6-8-2008 12:00 PM
Description
We examine the notion that cells in conditions of stress accumulate mutation is in genes under selection via transcription processes. CodY is a global transcriptional regulator in many Gram positives, including soil and pathogenic microbes. In conditions of exponential growth and when branch chain amino acids and GTP are in abundance CodY acts as a transcriptional repressor of many metabolic operons. This transitional repression saves the cell energy and allows efficient use of resources. In conditions of starvation, CodY relieves repression of genes involved in acquisition of nutrients and degradation of carbon sources (genes under selection). Here, we compare the accumulation of mutations in genes under selection in wild type and CodY.
Keywords
Bacillus subtilis; Cell growth; Gene mutation; Mutagenesis; Transcriptional regulators
Disciplines
Bacteriology | Microbiology
Language
English
The Effect of CodY on stationary phase mutagenesis in Bacillus subtilis
University of Nevada Las Vegas, Student Union Ball Room
We examine the notion that cells in conditions of stress accumulate mutation is in genes under selection via transcription processes. CodY is a global transcriptional regulator in many Gram positives, including soil and pathogenic microbes. In conditions of exponential growth and when branch chain amino acids and GTP are in abundance CodY acts as a transcriptional repressor of many metabolic operons. This transitional repression saves the cell energy and allows efficient use of resources. In conditions of starvation, CodY relieves repression of genes involved in acquisition of nutrients and degradation of carbon sources (genes under selection). Here, we compare the accumulation of mutations in genes under selection in wild type and CodY.
Comments
Abstract & poster