Location

University of Nevada Las Vegas, Science and Education Building

Start Date

9-8-2011 10:15 AM

End Date

9-8-2011 12:00 PM

Description

Cell migration is a vital component of metastasis. In this study, our intent was to study cell migration by alteration of the Wnt/GSK-3 Pathway. Since BeSO4 is a known GSK-3 kinase inhibitor, we hypothesized that this agent would cause cell migration to decrease as a result of β-catenin stabilization. Two human cell lines, HT-1080 (fibrosarcoma) and A172 (glioblastoma), were used to observe migration levels in the presence and absence of BeSO4. Our results show that cell migration is diminished for cells that were pre-treated with BeSO4, in comparison to the untreated (control) cells.

Disciplines

Biochemistry | Medicinal-Pharmaceutical Chemistry | Oncology

Language

English

Comments

Research sponsored by: NIH grant # P20 RR-016464


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Aug 9th, 10:15 AM Aug 9th, 12:00 PM

Cell migration dynamics after alteration of cell-cell contacts in fibrosarcoma and glioblastoma cell lines

University of Nevada Las Vegas, Science and Education Building

Cell migration is a vital component of metastasis. In this study, our intent was to study cell migration by alteration of the Wnt/GSK-3 Pathway. Since BeSO4 is a known GSK-3 kinase inhibitor, we hypothesized that this agent would cause cell migration to decrease as a result of β-catenin stabilization. Two human cell lines, HT-1080 (fibrosarcoma) and A172 (glioblastoma), were used to observe migration levels in the presence and absence of BeSO4. Our results show that cell migration is diminished for cells that were pre-treated with BeSO4, in comparison to the untreated (control) cells.

http://digitalscholarship.unlv.edu/cs_urop/2011/aug9/7