University of Nevada, Las Vegas; Center for Academic Enrichment and Outreach
The first platinum-based drug was discovered and approved by Food and Drug Administration (FDA) in 1978 is cis-diamminedichloroplatinum (II) (cisplatin or CDDP). Cisplatin is used for about 50% of the chemotherapeutic cancer treatments along with its two analogues carboplatin and oxaliplatin. So far these drugs have been used extensively as treatment for ovarian, bladder, head and neck, and lung cancers. Although cisplatin has been used so often, it has toxic side effects and drug resistance.1-4 Due to these limitations other compounds have been synthesized. Specifically, our lab in conjunction with a biochemistry lab has recently published one article in this area. This project is a continuation to the development of anticancer drugs.
Cancer; Cancer--Chemotherapy; Cancer--Treatment; Chemotherapy; Cisplatin
Biochemistry | Biochemistry, Biophysics, and Structural Biology | Cancer Biology | Life Sciences
Ciulei, M. A.,
Bhowmik, P. K.
Synthesis and Characterization of PT(II) Complexes for Anticancer Therapy.
Available at: http://digitalscholarship.unlv.edu/mcnair_posters/47