Title

Effects of cytokines on CNS cells: Glia

Document Type

Chapter

Abstract

Glial cells act as supportive and homeostatic cells for other glia and neurons in the CNS. However, glia are highly responsive to constituents of the local milieu, and their function is therefore subject to modulation by local factors, some of which may be cytokines. The specific effects of cytokines on glial cells include induction of cytokine production, regulation, and death. This chapter will describe studies that have examined how interferons, tumor necrosis factor, interleukins, colony stimulating factors, and transforming growth factor-βs, affect these properties of microglia, astrocytes, and oligodendrocytes. Rather than review the entire field over the last decade, only the most recent additions to the literature will be discussed.

Disciplines

Medicine and Health Sciences | Nursing