Title
Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression
Document Type
Article
Publication Date
2-1-2015
Publication Title
Journal of Affective Disorders
Volume
172
First page number:
307
Last page number:
311
Abstract
Shank3, a post-synaptic density protein involved in N-methyl-d-aspartate (NMDA) receptor tethering and dendritic spine rearrangement, is implicated in the pathophysiology of bipolar disorder. We hypothesized that elevated baseline plasma Shank3 levels might predict antidepressant response to the NMDA receptor antagonist ketamine.
Keywords
Ketamine; Bipolar depression; Shank3; MRI; PET
Disciplines
Nursing
Repository Citation
Ortiz, R.,
Niciu, M. J.,
Lukkahati, N.,
Saligan, L. N.,
Nugent, A. C.,
Luckenbaugh, D. A.,
Machado-Vieira, R.,
Zarate, Jr, C. A.
(2015).
Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression.
Journal of Affective Disorders, 172
307-311.
http://dx.doi.org/10.1016/j.jad.2014.09.015