Award Date

5-1-2013

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Health Physics and Diagnostic Sciences

First Committee Member

Steen Madsen

Second Committee Member

Ralf Sudowe

Third Committee Member

Gary Cerefice

Fourth Committee Member

Daniel Young

Number of Pages

64

Abstract

Treatments for glioblastoma multiforme and invasive ductal carcinoma involve surgical resection and adjuvant or concurrent targeted therapies. The goal of the secondary treatment is to reduce the cancer cells in the resection margin and other areas of suspected involvement. Photochemical internalization is a targeted therapy using light to activate photosensitizers embedded in cellular structures to improve the delivery of macromolecules within the cell.

In a previous study, optimized treatment parameters including radiant exposure, and irradiance, concentration of AlPcS(2a), temperature, and the concentration of bleomycin were determined for human ACBT glioma multicell spheroids. The current study investigates the effectiveness of the ACBT-optimized concurrent PCI/hyperthermia treatment for F98 rat glioma and MCF-7 human invasive ductal carcinoma spheroids. The combination of photochemical internalization and hyperthermia was shown to be more effective than either treatment modality alone and, in all cases, the combined treatments interacted in a synergistic manner.

Keywords

F98; Glioblastoma multiforme – Treatment; Heat – Physiological effect; Hyperthermia; MCF-7; Multicellular tumor spheroids; Photochemical internalization; Photochemotherapy; Photodynamic therapy; Phototherapy

Disciplines

Medicine and Health Sciences | Oncology | Physics

Language

English


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