Award Date

5-1-2015

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Health Physics and Diagnostic Sciences

First Committee Member

Steen Madsen

Second Committee Member

Henry Hirschberg

Third Committee Member

Bing Ma

Fourth Committee Member

Francis Cucinotta

Fifth Committee Member

Kai-Yu Ho

Sixth Committee Member

Kathryn H. Korgan

Number of Pages

62

Abstract

Although both chemotherapy and hyperthermia therapy have their inherent advantages, the non-specific targeting of chemotherapy and ineffectiveness of hyperthermia therapy alone suggests a better method can be developed. To overcome this problem, the combined treatment of chemotherapeutic agents with plasmonic photothermal therapy (PPTT) is proposed. This is the first study to investigate the efficacy of combined chemotherapy and PPTT using monocytes as delivery vehicles for gold nanoshells. The results of this investigation shows that PPTT combined with cisplatin resulted in some degree of synergism while additive effects were observed for concurrent treatments of PPTT and doxorubicin and PPTT and bleomycin.

Keywords

Chemotherapeutic Agents; Macrophage; Plasmonic Photothermal Therapy

Disciplines

Medical Sciences | Medicine and Health Sciences

Language

English


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