Award Date

May 2017

Degree Type

Thesis

Degree Name

Master of Public Health (MPH)

Department

Environmental and Occupational Health

First Committee Member

Guogen Shan

Second Committee Member

Paulo Pinheiro

Third Committee Member

Michelle Sotero

Fourth Committee Member

Daniel Young

Number of Pages

41

Abstract

Albumin, a protein that when found in urine, is an early indicator of Chronic Kidney Disease (CKD). Genetic contributions have been shown to illustrate the gene-environment interactions that may lead to CKD in an individual; however, few studies have highlighted the interaction between responses of gene variations associated with the risk of increased albumin in young adults. This study’s purpose is to evaluate the hypothesis that candidate genes are related to microalbuminuria in young adults of the third wave of the National Longitudinal Study of Adolescent Health (Add Health Wave III). This longitudinal study includes an assessment of various candidate genes typically reported to be associated with behavioral differences in individuals and urinalysis results collected from a large population of young adults. The data set also contains a twin & sibling sample that is analyzed to find an association between various genes while controlling for family relativity. Findings include an association found within the sibling sample between women and single nucleotide polymorphisms (SNPs), rs892413 & rs4950. A better understanding of genetic factors associated with kidney functioning in this age group could improve our knowledge of the complex genetics of kidney function as well as guide prevention and intervention methods.

Disciplines

Epidemiology

Language

English


Included in

Epidemiology Commons

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