Macrophages as Delivery Vehicles for Anticancer Agents
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The delivery of anticancer agents via passive approaches such as the enhanced permeability and retention effect is unlikely to achieve sufficient concentrations throughout the tumor volume for effective treatment. Cell-based delivery approaches using tumor tropic cells have the potential to overcome the limitations of passive approaches. Specifically, this review focuses on the use of monocytes/macrophages for the delivery of a variety of anticancer agents, including nanoparticles, chemotherapeutics and gene constructs. The efficacy of this delivery approach, both as monotherapy and in combination with light-based phototherapy modalities, has been demonstrated in numerous in vitro and animal studies, however, its clinical potential remains to be determined.
Chemotherapeutics; Gene therapy; Gliomas; Gold–silica nanoshells; Macrophages; monocytes; Nanoparticles; Photochemical internalization; Photodynamic therapy; Photothermal therapy
Medicinal and Pharmaceutical Chemistry
Madsen, S. J.,
Macrophages as Delivery Vehicles for Anticancer Agents.
Therapeutic Delivery, 10(3),