Title

Catalyst-free Synthesis of α1-oxindole-α-Hydroxyphosphonates Via Phospha-aldol Reaction of Isatins Employing N-heterocyclic Phosphine (NHP)-thiourea

Document Type

Article

Publication Date

9-9-2016

Publication Title

Organic & Biomoleculer Chemistry

Volume

14

Issue

38

First page number:

8952

Last page number:

8956

Abstract

A highly efficient phospha-aldol reaction for the synthesis of α1-oxindole-α-hydroxyphosphonates is developed utilizing N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodology encompasses a variety of isatin derivatives to provide α1-oxindole- α-hydroxyphosphonates up to 99% yield.

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