Title

Self-regulating Ubiquitin Ligases

Document Type

Article

Publication Date

1-1-2017

Publication Title

EMBO Journal

Abstract

Occasional auto-modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto-ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation. © 2017 EMBO.

Language

english

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