Self-regulating Ubiquitin Ligases
Occasional auto-modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto-ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation. © 2017 EMBO.
Self-regulating Ubiquitin Ligases.