Selective Hydrolysis of Phosphorus(V) Compounds to Form Organophosphorus Monoacids
Organic and Biomolecular Chemistry
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An azide and transition metal-free method for the synthesis of elusive phosphonic, phosphinic, and phosphoric monoacids has been developed. Inert pentavalent P(V)-compounds (phosphonate, phosphinate, and phosphate) are activated by triflate anhydride (Tf2O)/pyridine system to form a highly reactive phosphoryl pyridinium intermediate that undergoes nucleophilic substitution with H2O to selectively deprotect one alkoxy group and form organophosphorus monoacids.
Kang, J. Y.
Selective Hydrolysis of Phosphorus(V) Compounds to Form Organophosphorus Monoacids.
Organic and Biomolecular Chemistry(27),