Document Type

Conference Proceeding

Publication Date

1-1-2021

Publication Title

IOP Conference Series: Earth and Environmental Science

Publisher

IOP Publishing

Volume

779

Issue

1

First page number:

1

Last page number:

9

Abstract

New mono- and bis-dithiocarbamates were prepared from the reaction of organic dihydrazides -NHNH-(C=O)(CH2)x-(C=O)NHNH- (where x = 0, 2, 4) and basic carbon disulfide with varying chain length 10-14 atom as a human serum metal carrier. The products were characterized by various spectrophotometric such as 1H and 13C NMR and elemental analysis. Their antiproliferative activities were examined on two species of the standard strains of the Gram-positive Staphylococcus aureus ATCC 25923 and Gram-negative Escherichia coli ATCC 25922 by following the procedure of broth micro-dilution method (BMM), which was applied at the concentrations: 0.0, 100, 200, and 300 ppm for each compound. The antioxidant properties were investigated by following the DPPH method, which was applied for each of the above concentrations. All prepared compounds exhibited antiproliferative and antioxidant activity.

Keywords

Antioxidant; Antiproliferative activity; Dithiocarbamates; DPPH; Drug delivery; Metal carrier

Disciplines

Chemicals and Drugs | Medicine and Health Sciences

File Format

pdf

File Size

783 KB

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

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