Title

Triflic Anhydride (Tf < inf > 2 < /inf > O)-Activated Transformations of Amides, Sulfoxides and Phosphorus Oxides via Nucleophilic Trapping

Document Type

Article

Publication Date

3-1-2022

Publication Title

Synthesis (Germany)

Abstract

Trifluoromethanesulfonic anhydride (Tf2O) is utilized as a strong electrophilic activator in a wide range of applications in synthetic organic chemistry, leading to the transient generation of a triflate intermediate. This versatile triflate intermediate undergoes nucleophilic trapping with diverse nucleophiles to yield novel compounds. In this review, we describe the features and applications of triflic anhydride in organic synthesis reported in the past decade, especially in amide, sulfoxide, and phosphorus oxide chemistry through electrophilic activation. A plausible mechanistic pathway for each important reaction is also discussed.

Keywords

Amides; Electrophilic activation; Phosphonium triflate; Phosphorus oxides; Sulfoxides; Triflic anhydride

Disciplines

Biochemistry | Molecular Biology

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