Cefoxitin vs. Penicillin in the Treatment of Uncomplicated Gonorrhea
Four hundred six men and women with gonorrhea were randomly assigned to receive either 2 g of cefoxitin or 4.8 X 10(6) units of aqueous procaine penicillin G intramuscularly. All patients also received 1 g of probenecid orally. There was no statistically significant difference in the failure rate between patients treated with penicillin (4.3%) and those treated with cefoxitin (5.1%). Twelve (92%) of 13 homosexual men with gonococcal proctitis who received penicillin and 19 (95%) of 20 who received cefoxitin were cured. Adverse reactions were infrequent and mild in the cefoxitin-treated group. Three patients who received penicillin developed reactions consistent with procaine toxicity. It is concluded that cefoxitin is a safe and effective alternative to penicillin for treating uncomplicated anogenital gonorrhea in men and women.
Antibiotics; Clinical trials; Drugs – Testing; Gonorrhea
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Community Health | Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Pharmacy and Pharmaceutical Sciences
Use Find in Your Library, contact the author, or use interlibrary loan to garner a copy of the article. Publisher copyright policy allows author to archive post-print (author’s final manuscript). When post-print is available or publisher policy changes, the article will be deposited
Greaves, W. L.,
Kraus, S. J.,
McCormack, W. M.,
Fiumara, N. J.,
Cefoxitin vs. Penicillin in the Treatment of Uncomplicated Gonorrhea.
Sexually Transmitted Diseases, 10(2),