Associations between Comorbid TDP-43, Lewy Body Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease
Journal of Alzheimer's Disease
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More than half of the patients with Alzheimer’s disease (AD) have comorbidities including TDP-43 and Lewy bodies, which are also associated with frontotemporal lobar degeneration and dementia with Lewy bodies, respectively. These comorbidities may help explain the overlapping neuropsychiatric symptoms between AD and other dementias. Data on 221 AD patients with Neuropsychiatric Inventory-Questionnaire were obtained from the National Alzheimer’s Coordinating Center. TDP-43 was associated with aberrant motor activity, whereas Lewy bodies were associated with anxiety, irritability, sleep behavior, and appetite problems. The associations between these comorbidities and neuropsychiatric symptoms were more significant for patients with sparse diffuse plaques.
Alzheimer's Disease, Lewy body; Neuropsychiatric symptoms: TDP-43
Cognitive Neuroscience | Mental Disorders | Nutritional Epidemiology
Cummings, J. L.
Associations between Comorbid TDP-43, Lewy Body Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease.
Journal of Alzheimer's Disease, 69(4),