Epidemic Occurrence of Neonatal Necrotizing Enterocolitis
First page number:
Last page number:
In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC.
Antibiotics; Enterocolitis; Neonatal necrotizing
Digestive System | Digestive System Diseases | Gastroenterology | Pediatrics
Use Find in Your Library, contact the author, or use interlibrary loan to garner a copy of the article. Publisher copyright policy allows author to archive post-print (author’s final manuscript). When post-print is available or publisher policy changes, the article will be deposited
Bruhn, F. W.,
Fox, W. W.
Epidemic Occurrence of Neonatal Necrotizing Enterocolitis.
JAMA Pediatrics, 133(6),