Location
University of Nevada, Las Vegas
Start Date
3-8-2010 9:00 AM
End Date
3-8-2010 12:00 PM
Description
Osteoarthritis (OA) is a debilitating disease that affects an estimated 27 million adults in the United States. OA causes damage to cartilage in the joints resulting in bones that rub together. This creates pain, swelling, loss of motion of the joint, and bone spurs. As the number of adults above 65 grows (an estimated 72 million people by 2030) even more people will be at high risk for OA. It is the most common type of arthritis by far yet very little is known about it including relationships between joint structure and function. In 2004, the NIH created the Osteoarthritis Initiative (OAI) which tracks participants for 5 years looking for physical signs that indicate changes in the joint cartilage [1]. Other research includes the creation of diagnostic tools to detect onset of the disease. Genetic studies search for ties between OA and gene mutations. This research involves the creation of accurate 3D models to determine the in-vivo function in the guinea pig knee model of osteoarthritis. These models will be created using a 3D imaging technique called, X-Ray Reconstruction of Moving Morphology(XROMM).
Keywords
Guinea pigs – Locomotion; Guinea pigs – Physiology; Knee; Osteoarthritis
Disciplines
Animal Sciences | Biomechanics and Biotransport | Biomedical Engineering and Bioengineering | Engineering | Life Sciences
Language
English
3d micro-mr and micro-ct models for determining in-vivo function in the Guinea Pig knee model of Osteoarthritis (OA)
University of Nevada, Las Vegas
Osteoarthritis (OA) is a debilitating disease that affects an estimated 27 million adults in the United States. OA causes damage to cartilage in the joints resulting in bones that rub together. This creates pain, swelling, loss of motion of the joint, and bone spurs. As the number of adults above 65 grows (an estimated 72 million people by 2030) even more people will be at high risk for OA. It is the most common type of arthritis by far yet very little is known about it including relationships between joint structure and function. In 2004, the NIH created the Osteoarthritis Initiative (OAI) which tracks participants for 5 years looking for physical signs that indicate changes in the joint cartilage [1]. Other research includes the creation of diagnostic tools to detect onset of the disease. Genetic studies search for ties between OA and gene mutations. This research involves the creation of accurate 3D models to determine the in-vivo function in the guinea pig knee model of osteoarthritis. These models will be created using a 3D imaging technique called, X-Ray Reconstruction of Moving Morphology(XROMM).
Comments
Poster research sponsored by NIH INBRE