Efficacy of an Anhydrous Stannous Fluoride Toothpaste for Relief of Dentine Hypersensitivity: A Randomized Clinical Study
Journal of Clinical Periodontology
First page number:
Last page number:
Aim To compare efficacy of an anhydrous 0.454% w/w stannous fluoride/sodium fluoride toothpaste (Test) versus a sodium monofluorophosphate toothpaste (Negative control) and a stannous chloride/sodium fluoride toothpaste (Positive control) for dentine hypersensitivity relief after 8 weeks’ twice-daily use. Materials and Methods In this randomized, examiner-blind, stratified, parallel study, primary and secondary efficacy variables were mean changes in Schiff score (evaporative [air] sensitivity) and tactile threshold (Yeaple probe), respectively, from baseline to Week 8 between Test (n = 62) and Negative control (n = 62). Test and Positive control (n = 61) comparisons were exploratory objectives. Results All groups significantly improved from baseline on both dentine hypersensitivity measures (p < .0001). Difference between adjusted mean changes from baseline in Schiff sensitivity scores at Week 8 for Test versus Negative control groups was 0.19 (95% CI 0.002, 0.374), in favour of the Negative control (p = .0476; 12.57% difference). Difference in tactile threshold was −7.20 g (95% CI −16.376, 1.975), and this was not statistically significant (p = .3715; −21.83% difference). Test group showed no significant difference versus Positive control for either measure. Toothpastes were generally well tolerated. Conclusion While twice-daily use of Test toothpaste significantly reduced dentine hypersensitivity from baseline, there was no significant advantage over negative or positive controls. Study registration: Clinicaltrials.gov; NCT03310268.
Dentifrice; Dentine sensitivity; Pain; Stannous fluoride; Toothpaste
Dental Hygiene | Dentistry | Medicine and Health Sciences
Ling, M. R.,
Efficacy of an Anhydrous Stannous Fluoride Toothpaste for Relief of Dentine Hypersensitivity: A Randomized Clinical Study.
Journal of Clinical Periodontology, 47(8),