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Loss of function lesions in Ubiquitin-specific protease (USP) 7 are associated with intellectual disability, speech delay, autism spectrum disorder, and seizures. While the deubiquitinating activity of USP7 has been characterized in cancer, its role in neurological conditions is not understood. Here, we show that USP7 can regulate the development of the brain by localizing to synaptosomes in the hippocampus and stabilizing neural-specific substrates.
Las Vegas (Nev.)
University of Nevada, Las Vegas
Brain--Localization of functions
Neuroscience and Neurobiology
Itorralba, Jose; Boss, Sage; Akbar, Shahraiz; Baker, Hayley; and Chang, Chinglan, "Characterization of USP7 substrates in the brain" (2022). Undergraduate Research Symposium Posters. 127.
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Faculty Mentors: Edwin C. Oh, Van Vo