Download

Download Full Text (1.4 MB)

Description

Hook3 (Hook Microtubule Tethering Protein 3) is a gene that encodes a protein that is localized in the Golgi complex and is linked to cellular trafficking of cargos and the binding of microtubules to organelles. Although there is some literature discussing the known functions of the gene, the phenotypes in mice or humans have not been thoroughly researched and literature on these phenotypes is limited. The literature that is available suggests Hook3 is implicated in diverse phenotypes ranging from bone development to neural development in mice. Since Hook3 is associated with prostate cancer, it is likely that it is involved in other types of cancers as well. To investigate this, an online database called cBioPortal was used to determine if there are changes in Hook3 expression or mutations in different kinds of cancers including breast, lung, prostate, brain/CNS, and cervical. Two main pieces of data gathered were mutation types and protein changes relevant to Hook3.

Publication Date

Spring 2021

Language

English

Keywords

Neurogenetics; Cancer; Mutations; Hook3

Disciplines

Medical Genetics

File Format

pdf

File Size

1408 KB

Comments

Faculty Mentor: Edwin Oh, Ph.D.

Hook3 Mutations and Their Contributions to Different Types of Cancers


Share

COinS