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Hook3 (Hook Microtubule Tethering Protein 3) is a gene that encodes a protein that is localized in the Golgi complex and is linked to cellular trafficking of cargos and the binding of microtubules to organelles. Although there is some literature discussing the known functions of the gene, the phenotypes in mice or humans have not been thoroughly researched and literature on these phenotypes is limited. The literature that is available suggests Hook3 is implicated in diverse phenotypes ranging from bone development to neural development in mice. Since Hook3 is associated with prostate cancer, it is likely that it is involved in other types of cancers as well. To investigate this, an online database called cBioPortal was used to determine if there are changes in Hook3 expression or mutations in different kinds of cancers including breast, lung, prostate, brain/CNS, and cervical. Two main pieces of data gathered were mutation types and protein changes relevant to Hook3.
Neurogenetics; Cancer; Mutations; Hook3
Mikhaiel, Brittny and Vo, Van Ph.D., "Hook3 Mutations and Their Contributions to Different Types of Cancers" (2021). Undergraduate Research Symposium Posters. 20.