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Alzheimer’s disease (AD) is a detrimental, progressive neurodegenerative disease that is regarded as the most common and pervasive form of dementia, affecting an estimated 1 in 14 people over the age of 65 and 1 in every 6 people over the age of 80.1,2 Diagnosing AD at the proper time poses a great challenge in the current clinical setting. Traditional methods for the diagnosis of AD are expensive, provide poor resolution, and involve toxic radioactive materials. This study aims to synthesize a class of novel fluorescent molecular probes that can bind to the protein-plaques that are caused by the onset of AD to ultimately provide a safe and effective method to diagnose the early stages of AD through improved in vivo imaging, potentially becoming an indispensable tool for diagnosis. The final fluorescent molecular probe was synthesized from a simple Sn2 reaction involving a precursor and was characterized using 1H and 13C nuclear magnetic resonance spectra, elemental analysis, thermogravimetric analysis, and solubility properties. The resultant fluorescent molecular probe was successfully synthesized and emits white-light fluorescence in the solution-state when dissolved in water, making it suitable for aqueous systems. Further studies can be expanded upon for in vivo imaging studies, toxicity, and suitability for the clinical setting.

Publication Date

Fall 11-15-2021




Alzheimer's; Synthesis; Fluorescence; Diagnosis; Medicine

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632 KB


Faculty Mentor: Haesook Han, Ph.D.


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Synthesis of Novel Fluorescent Probes for the Early Diagnosis of Alzheimer’s Disease