Open Access Journal of Clinical Trials
Dove Medical Press
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Objective This study examines whether men-who-have-sex-with-men (MSM) and transgender (TG) persons’ attitudes, beliefs, and risk perceptions toward human immunodeficiency virus (HIV) vaccine research have been altered as a result of the negative findings from a phase 2B HIV vaccine study. Design We conducted a cross-sectional survey among MSM and TG persons (N = 176) recruited from community settings in Atlanta from 2007 to 2008. The first group was recruited during an active phase 2B HIV vaccine trial in which a candidate vaccine was being evaluated (the “Step Study”), and the second group was recruited after product futility was widely reported in the media. Methods Descriptive statistics, t tests, and chi-square tests were conducted to ascertain differences between the groups, and ordinal logistic regressions examined the influences of the above-mentioned factors on a critical outcome, future HIV vaccine study participation. The ordinal regression outcomes evaluated the influences on disinclination, neutrality, and inclination to study participation. Results Behavioral outcomes such as future recruitment, event attendance, study promotion, and community mobilization did not reveal any differences in participants’ intentions between the groups. … See full text for complete abstract.
AIDS; Men-who-have-sex-with-men; Recruitment; Community engagement; Willingness to participate
Health Services Research | Immunology of Infectious Disease | Lesbian, Gay, Bisexual, and Transgender Studies | Virology
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This work is licensed under a Creative Commons Attribution 4.0 License.
Frew, P. M.,
Mulligan, M. J.,
del Rio, C.
Time Will Tell: Community Acceptability of HIV Vaccine Research Before and After the "Step Study" Vaccine Discontinuation.
Open Access Journal of Clinical Trials, 2010(2),
Dove Medical Press.