Maternal Cadmium Exposure and Neurobehavior in Children: The HOME Study
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Background: It is unclear whether cadmium (Cd) exposure during fetal brain development is associated with child neurobehavior. Objective: To examine the potential associations between Cd exposure during pregnancy and neurobehavior among children. Methods: We used data from 276 children in the Health Outcomes and Measures of the Environment (HOME) Study, a well-established prospective pregnancy and birth cohort. We measured maternal urinary Cd concentrations at 26 weeks of gestation. For cognitive function, we assessed Mental Development Index (MDI) and Full-Scale Intelligence Quotient (FSIQ) using the Bayley Scales of Infant Development-II, the Wechsler Preschool and Primary Scales of Intelligence-III, or the Wechsler Intelligence Scales for Children-IV at ages 1, 2, 3, 5, and 8 years. We assessed child behaviors using the Behavior Assessment System for Children-2 at ages 2, 3, 4, 5, and 8 years, yielding four composite measures: Externalizing Problems, Internalizing Problems, Behavioral Symptoms Index, and Adaptive Skills. We used linear mixed models with covariate adjustment to estimate the associations between maternal urinary Cd concentrations and child neurobehavior. Results: We categorized study participants into three groups based on maternal urinary Cd concentrations (Group 1...) (See full abstract in article).
Cadmium; Prenatal exposure; Child development; Neurobehavior
Environmental Health | Maternal and Child Health | Toxicology
Vuong, A. M.,
Dietrich, K. N.,
Karagas, M. R.,
Lanphear, B. P.,
Braun, J. M.,
Maternal Cadmium Exposure and Neurobehavior in Children: The HOME Study.
Environmental Research, 186