Can Vitamin E Slow Down Mild Cognitive Impairment in Elderly People?

Document Type

Conference Proceeding

Publication Date


Publication Title

Proceedings of the American Public Health Association Annual Meeting


Background: With the aging population, dementia is becoming a growing public health concern. In 2012, Health and Retirement Study found that 8.8% of adults over 65 years suffered from dementia. The etiopathogenesis and treatment of dementia are not well understood. Antioxidant properties of Vitamin E and its major elements tocopherols and tocotrienols have been reported to be effective in reducing the progression of dementia. Mild cognitive impairment (MCI) is an initial stage of dementia. Objectives: This scoping review examined the role of Vitamin E on MCI. Methods: A narrative literature search using the key words “Vitamin E, tocopherols, tocotrienols, and mild cognitive impairment” was conducted in MEDLINE (PubMed), CINAHL, and Google Scholar. The inclusion criteria were: (1) articles published in the past ten years; (2) in English language; (3) published in peer-reviewed journals; and (4) all accounts of descriptive and epidemiological or evaluation studies. Articles published prior to 2010, focused on other forms of dementia than MCI, published in grey literature and in non-peer-reviewed journals were excluded. Results: A total of 23 studies were included in the analysis. Mixed results were found. Eleven studies showed some level of the neuroprotective effect of Vitamin E, tocopherols and tocotrienols on the progression of MCI. Conclusion: The mixed results of this review suggest further exploration of the possible protective effects of Vitamin E on the development of dementia. Large scale randomized trials on the effectiveness of various elements of Vitamin E on the decline of the mental function should be carried out.


Aging population; Dementia; Public health concern; Elderly people; Vitamin E; Mild cognitive impairment; Mental function


Cognition and Perception | Psychology | Social and Behavioral Sciences



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