Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones
American Journal of Epidemiology
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Production of organophosphate esters (OPEs), which represent a major flame-retardant class present in consumer goods, has increased over the past 2 decades. Experimental studies suggest that OPEs may be associated with thyroid hormone disruption, but few human studies have examined this association. We quantified OPE metabolites in the urine of 298 pregnant women from Cincinnati, Ohio, in the Health Outcomes and Measures of the Environment Study (enrolled 2003-2006) at 3 time points (16 and 26 weeks' gestation, and at delivery), and thyroid hormones in 16-week maternal and newborn cord sera. Urinary bis(1,3-dichloro-2-propyl)-phosphate concentrations were generally associated with decreased triiodothyronine and thyroxine levels and increased thyroid-stimulating hormone levels in maternal and newborn thyroid hormones in quartile dose-response analyses and multiple informant models. There was weaker evidence for thyroid hormone alterations in association with diphenyl-phosphate and di-n-butyl-phosphate. Bis-2-chloroethyl-phosphate was not associated with alterations in thyroid hormones in any analyses. We did not observe any evidence of effect modification by infant sex. These results suggest that gestational exposure to some OPEs may influence maternal and neonatal thyroid function, although replication in other cohorts is needed.
Cohort studies; Flame retardants; Pregnancy; Thyroid hormones
Hormones, Hormone Substitutes, and Hormone Antagonists | Maternal and Child Health
Vuong, A. M.,
Lanphear, B. P.,
Braun, J. M.,
Cecil, K. M.,
Dietrich, K. N.,
Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones.
American Journal of Epidemiology, 190(9),
Available at: http://dx.doi.org/10.1093/aje/kwab086