Title
Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides
Document Type
Article
Publication Date
1-1-2017
Publication Title
Organic Letters
Volume
19
Issue
21
First page number:
5988
Last page number:
5991
Abstract
A new class of Brønsted acid catalysts based on N-heterocyclic phosphorodiamidic acids (NHPAs) has been developed. The NHPA catalyst promotes phospha-Michael addition reaction of trialkylphosphites to in situ generated ortho-quinone methides (o-QMs) for the construction of diaryl phosphonates in moderate to excellent yields with 1.5 mol % catalyst. Diastereoselective synthesis of P-chiral phosphinate esters is achieved with the use of dialkyl phenylphosphonites. © 2017 American Chemical Society.
Language
english
Repository Citation
Huang, H.,
Kang, J. Y.
(2017).
Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides.
Organic Letters, 19(21),
5988-5991.
http://dx.doi.org/10.1021/acs.orglett.7b03019