Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides

Document Type

Article

Publication Date

1-1-2017

Publication Title

Organic Letters

Volume

19

Issue

21

First page number:

5988

Last page number:

5991

Abstract

A new class of Brønsted acid catalysts based on N-heterocyclic phosphorodiamidic acids (NHPAs) has been developed. The NHPA catalyst promotes phospha-Michael addition reaction of trialkylphosphites to in situ generated ortho-quinone methides (o-QMs) for the construction of diaryl phosphonates in moderate to excellent yields with 1.5 mol % catalyst. Diastereoselective synthesis of P-chiral phosphinate esters is achieved with the use of dialkyl phenylphosphonites. © 2017 American Chemical Society.

Language

english

UNLV article access

Search your library

Share

COinS