Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides
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A new class of Brønsted acid catalysts based on N-heterocyclic phosphorodiamidic acids (NHPAs) has been developed. The NHPA catalyst promotes phospha-Michael addition reaction of trialkylphosphites to in situ generated ortho-quinone methides (o-QMs) for the construction of diaryl phosphonates in moderate to excellent yields with 1.5 mol % catalyst. Diastereoselective synthesis of P-chiral phosphinate esters is achieved with the use of dialkyl phenylphosphonites. © 2017 American Chemical Society.
Kang, J. Y.
Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides.
Organic Letters, 19(21),