Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma
Document Type
Article
Publication Date
9-24-2021
Publication Title
Journal of Hepatocellular Carcinoma
Volume
8
First page number:
1169
Last page number:
1179
Abstract
Localized hepatocellular carcinoma (HCC) that is unresectable and non-transplantable can be treated by several liver-directed therapies. External beam radiation therapy (EBRT) is an increasingly accepted and widely utilized treatment modality in this setting. Accelerated charged particles such as proton beam therapy (PBT) and carbon ion radiation therapy (CIRT) offer technological advancements over conventional photon radiotherapy. In this review, we summarize the distinct advantages of CIRT use for HCC treatment, focusing on physical and biological attributes, and outline dosimetric and treatment planning caveats. Based on these considerations, we posit that HCC may be among the best indications for use of CIRT, as it allows for maximizing tumoricidal doses to the target volume while minimizing the dose to the organs at risk.
Keywords
carbon ion therapy; hepatocellular carcinoma; hypofractionation
Disciplines
Radiology
Repository Citation
Abousaida, B.,
Seneviratne, D.,
Hoppe, B. S.,
Ko, S. J.,
Asaithamby, A.,
Cucinotta, F. A.,
Kirwan, J. M.,
Mody, K.,
Toskich, B.,
Ashman, J. B.,
Hallemeier, C. L.,
Krishnan, S.
(2021).
Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma.
Journal of Hepatocellular Carcinoma, 8
1169-1179.
http://dx.doi.org/10.2147/JHC.S292516