Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study

Authors

Steen J. Madsen, University of Nevada, Las VegasFollow
En-Chung Shih, University of Nevada, Las VegasFollow
Qian Peng, Oslo University HospitalFollow
Catherine Christie, Beckman Laser Institute and Medical ClinicFollow
Tatiana Krasieva, Beckman Laser Institute and Medical ClinicFollow
Henry Hirschberg, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

1-1-2016

Publication Title

Journal of Biomedical Optics

Volume

21

Issue

1

Abstract

Moderate hyperthermia (MHT) has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of commonly used chemotherapeutic agents with MHT induced by near-infrared (NIR) activation of gold nanoshell (AuNS)-loaded macrophages (Ma). AuNS-loaded murine Ma combined with human FaDu squamous cells, in hybrid monolayers, were subjected to three cytotoxic drugs (doxorubicin, bleomycin, cisplatin) with or without NIR laser irradiation. For all three drugs, efficacy was increased by NIR activation of AuNS-loaded Ma. The results of this

Repository Citation

Madsen, S. J., Shih, E., Peng, Q., Christie, C., Krasieva, T., Hirschberg, H. (2016). Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study. Journal of Biomedical Optics, 21(1),
http://dx.doi.org/10.1117/1.JBO.21.1.018004