Document Type
Article
Publication Date
4-3-2018
Publication Title
Scientific Reports
Volume
8
Abstract
Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, gamma-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive decrements. The in silico representations are used in a stochastic model that describes time dependent dendritic damage induced by exposure to low LET radiation. Changes in morphometric parameters, such as total dendritic length, number of branch points and branch number, including the Sholl analysis for single neurons are described by the model. Our model based predictions for different patterns of morphological changes based on energy deposition in dendritic segments (EDDS) will serve as a useful basis to compare specific patterns of morphological alterations caused by EDDS mechanisms.
Keywords
Carbon-Ion-Beams; Adult Neurogenesis; Pyramidal Neurons; X-Irradiation; Cognitive Dysfunction; Cancer-Therapy; Chronic Stress; Dentate Gyrus; Morphology; Cells
Disciplines
Neurology | Oncology | Radiology
File Format
application/pdf
File Size
5.165 Kb
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Cacao, E.,
Parihar, V. K.,
Limoli, C. L.,
Cucinotta, F. A.
(2018).
Stochastic Modeling of Radiation-induced Dendritic Damage on in Silico Mouse Hippocampal Neurons.
Scientific Reports, 8
http://dx.doi.org/10.1038/s41598-018-23855-9