Title

Predictions of Cognitive Detriments from Galactic Cosmic Ray Exposures to Astronauts on Exploration Missions

Document Type

Article

Publication Date

10-16-2019

Publication Title

Life Sciences in Space Research

First page number:

1

Last page number:

7

Abstract

For the first-time we report on predictions on cognitive detriments from galactic cosmic ray (GCR) exposures on long-duration space missions outside the protection of the Earth's magnetosphere and solid body shielding. Estimates are based on a relative risk (RR) model of the fluence response for proton and heavy ion in rodent studies using the widely used novel object recognition (NOR) test, which estimates detriments in recognition or object memory. Our recent meta-analysis showed that linear and linear-quadratic dose response models were not accurate, while exponential increasing fluence response models based on particle track structure provided good descriptions of rodent data for doses up to 1 Gy. Using detailed models of the GCR environment and particle transport in shielding and tissue, we predict the excess relative risk (ERR) for NOR detriments for several long-term space mission scenarios. Predictions suggest ERR... (See article for full abstract).

Keywords

Space radiation; Novel object recognition; Cognitive detriments; Galactic cosmic rays; Track structure models; Voyager I measurements

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Environmental Health | Toxicology

Language

English

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