Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Document Type
Article
Publication Date
11-10-2020
Publication Title
Radiation Research
Volume
194
Issue
5
First page number:
452
Last page number:
464
Abstract
©2020 by Radiation Research Society. All rights of reproduction in any form reserved. The limited impact of treatments for COVID-19 has stimulated several phase 1 clinical trials of whole-lung low-dose radiation therapy (LDRT; 0.3-1.5 Gy) that are now progressing to phase 2 randomized trials worldwide. This novel but unconventional use of radiation to treat COVID-19 prompted the National Cancer Institute, National Council on Radiation Protection and Measurements and National Institute of Allergy and Infectious Diseases to convene a workshop involving a diverse group of experts in radiation oncology, radiobiology, virology, immunology, radiation protection and public health policy. The workshop was held to discuss the mechanistic underpinnings, rationale, and preclinical and emerging clinical studies, and to develop a general framework for use in clinical studies. Without refuting or endorsing LDRT as a treatment for COVID-19, the purpose of the workshop and this review is to provide guidance to clinicians and researchers who plan to conduct preclinical and clinical studies, given the limited available evidence on its safety and efficacy.
Disciplines
Radiation Medicine
Language
English
Repository Citation
Prasanna, P.,
Woloschak, G.,
DiCarlo, A.,
Buchsbaum, J.,
Schaue, D.,
Chakravarti, A.,
Cucinotta, F.,
Formenti, S.,
Guha, C.,
Hu, D.,
Khan, M.,
Kirsch, D.,
Krishnan, S.,
Leitner, W.,
Marples, B.,
McBride, W.,
Mehta, M.,
Rafii, S.,
Sharon, E.,
Sullivan, J.,
Weichselbaum, R.,
Ahmed, M.,
Vikram, B.,
Coleman, C.,
Held, K.
(2020).
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?.
Radiation Research, 194(5),
452-464.
http://dx.doi.org/10.1667/RADE-20-00211.1