Document Type
Article
Publication Date
10-8-2021
Publication Title
Medicine
Volume
100
Issue
40
First page number:
1
Last page number:
7
Abstract
ABSTRACT: Pneumonia is a common disease-causing hospitalization. When a healthcare-associated infection is suspected, antibiotics that provide coverage for multi-drug resistant (MDR) or extended-spectrum beta-lactamase (ESBL) bacteria are frequently prescribed. Limited data is available for guidance on using meropenem as a first-line empiric antimicrobial in hospitalized patients with risk factors for MDR/ESBL bacterial infections. This was a single-center, retrospective study designed and conducted to identify factors associated with positive cultures for MDR/ESBL pathogens in hospitalized patients with suspected healthcare-associated pneumonia.Of the 246 patients, 103 patients (41%) received meropenem. Among patients prescribed meropenem, MDR/ESBL pathogens were detected in only 20 patients (13%). Patients admitted from a skilled nursing facility/long-term acute care (SNF/LTAC) or with a history of a positive culture for MDR/ESBL pathogens were significantly associated with positive cultures of MDR/ESBL pathogens during the hospitalization (odds ratio [95% confidence intervals], 31.40 [5.20-189.6] in SNF/LTAC and 18.50 [2.98-115.1] in history of culture-positive MDR/ESBL pathogen). There was no significant difference in mortality between the 3 antibiotic groups.Admission from a SNF/LTAC or having a history of cultures positive for MDR/ESBL pathogens were significantly associated with a positive culture for MDR/ESBL pathogens during the subsequent admission. We did not detect significant association between meropenem use as a first-line drug and morbidity and mortality for patients admitted to the hospital with suspected healthcare-associated pneumonia, and further prospective studies with larger sample size are needed to confirm our findings.
Controlled Subject
Antibiotics; Pneumonia
Disciplines
Immunology and Infectious Disease
File Format
File Size
405 KB
Rights
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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Repository Citation
Kirsch, N.,
Ha, J.,
Kang, H.,
Frisch, T.,
Yoo, J.,
Grossman, C.,
Oroomchi, N.,
Shigemitsu, H.,
Cross, C.,
Kioka, M.
(2021).
Factors Associated With the Appropriate Use of Ultra-Broad Spectrum Antibiotics, Meropenem, for Suspected Healthcare-Associated Pneumonia.
Medicine, 100(40),
1-7.
Available at:
http://dx.doi.org/10.1097/MD.0000000000027488