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Known historically from Utah, Nevada, and Arizona, the relict leopard frog now only occurs naturally in two areas in southern Nevada. Although the species likely declined due to introduced competitors and predators and changes in habitat, a new threat has emerged in recent years. A globally dispersed pathogen that is decimating amphibian populations worldwide now threatens the recovery of these frogs. Ongoing research aims to determine the usefulness of vaccinations to help these animals fight off disease with the ultimate goal of reintroducing frogs to areas where the pathogen has invaded.