Resting Extracellular Signal-Regulated Protein Kinase 1/2 Expression Following a Continuum of Chronic Resistance Exercise Training Paradigms
Extracellular signal-regulated protein kinase 1/2 (ERK1/2) moderates skeletal muscle growth; however, chronic responses of this protein to unique resistance exercise (RE) paradigms are yet to be explored. The purpose of this investigation was to describe the long-term response of ERK1/2 following circuit weight training (CWT), recreationally weight training (WT), powerlifting (PL) and weightlifting (WL). Independent t-tests were used to determine differences in trained groups compared to sedentary controls. Total ERK1/2 content was lower in PL and WL compared to their controls (p ≤ 0.05). Specific trained groups displayed large (WL: pERK/total-ERK; d = 1.25) and moderate (CWT: total ERK1/2; d = 0.54) effect sizes for altered kinase expression compared to controls. The results indicate ERK1/2 expression is down-regulated after chronic RE in well-trained weightlifters and powerlifters. Lower expression of this protein may be a method in which anabolism is tightly regulated after many years of high-intensity RE.
Galpin, A. J.,
Fry, A. C.,
Nicoll, J. X.,
Moore, C. A.,
Schilling, B. K.,
Thomason, D. B.
Resting Extracellular Signal-Regulated Protein Kinase 1/2 Expression Following a Continuum of Chronic Resistance Exercise Training Paradigms.
Research in Sports Medicine, 24(3),