Title

Effects of Resistance Training on Hepcidin Levels and Iron Bioavailability in Older Individuals with End-Stage Renal Disease: A Randomized Controlled Trial

Document Type

Article

Publication Date

10-1-2020

Publication Title

Experimental Gerontology

Volume

139

First page number:

1

Last page number:

6

Abstract

Anemia is an inherent complication of older individuals with end-stage renal disease (ESRD) that is associated with inflammation which in turn is an important factor in the activation of hepcidin that contributes to the decrease in serum iron. Athough resistance training (RT) seems to reduce inflammation in ESRD, its influence on hepcidin and iron availability in hemodialysis patients is unclear. Therefore, the aim of this study was to exemine the effects of RT in on inflammatory profile, hepcidin, and iron status in older individuals with ESRD. Endstage renal disease patients (N: 157, age: 66.8 ± 3.6; body mass: 73 ± 15 body mass index:27 ± 3), were assigned to control (CTL n: 76) and exercise groups (RT n: 81). RT consisted of 24 weeks/3 days per week of a moderate intensity. There was an increase in the bioavailability of iron (ΔRT: 22.2; ΔCTL: −1 μg/dL, p < 0.0001), a decrease in hepcidin levels (ΔRT: -7.9; ΔCTL: 0.2 ng/mL, p < 0.0001),and an improvement of the inflammatory profile. These novel findings show that RT is a potential coadjuvant to reduce iron deficiency by decreasing the levels of hepcidin and pro-inflammatory markers in older patients undergoing hemodialysis.

Keywords

Resistance training; Nephrology; Hepcidin; Hematology; Cytokines; Hemodialysis

Disciplines

Diseases | Medicine and Health Sciences | Nutritional and Metabolic Diseases

Language

English

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