Inhaled Albuterol Increases Estimated Ventilatory Capacity in Nonasthmatic Children Without and With Obesity

Document Type

Article

Publication Date

3-1-2021

Publication Title

Respiratory Physiology and Neurobiology

Volume

285

First page number:

1

Last page number:

7

Abstract

© 2020 Elsevier B.V. Forced mid-expiratory flow (i.e., isoFEF25−75) may increase with a short-acting β2-agonist in nonasthmatic children without bronchodilator responsiveness. This could also increase estimated ventilatory capacity along mid-expiration (V̇Ecap25−75), especially in vulnerable children with obesity who exhibit altered breathing mechanics. We estimated V̇Ecap25−75 pre- and post-albuterol treatment in 8−12yo children without (n = 28) and with (n = 46) obesity. A two-way ANOVA was performed to determine effects of an inhaled bronchodilator (pre-post) and obesity (group) on isoFEF25−75 and V̇Ecap25−75. There was no group by bronchodilator interaction or main group effect on outcome variables. However, a significant main effect of the bronchodilator was detected in spirometry parameters, including a substantial increase in isoFEF25−75 (17.1 ± 18.0 %) and only a slight (non-clinical) but significant increase in FEV1 (2.4 ± 4.3 %). V̇Ecap25−75 significantly increased with albuterol (+11.7 ± 10.6 L/min; +15.8 ± 13.9 %). These findings imply potentially important increases in ventilatory reserve with a bronchodilator in nonasthmatic children without and with obesity, which could potentially influence respiratory function at rest and during exercise.

Keywords

Bronchodilator; FEF 25-75; FEV 1; Forced expiratory flow; Responsiveness; Spirometry

Disciplines

Circulatory and Respiratory Physiology | Molecular and Cellular Neuroscience

Language

English

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