Inhaled Albuterol Increases Estimated Ventilatory Capacity in Nonasthmatic Children Without and With Obesity
Document Type
Article
Publication Date
3-1-2021
Publication Title
Respiratory Physiology and Neurobiology
Volume
285
First page number:
1
Last page number:
7
Abstract
© 2020 Elsevier B.V. Forced mid-expiratory flow (i.e., isoFEF25−75) may increase with a short-acting β2-agonist in nonasthmatic children without bronchodilator responsiveness. This could also increase estimated ventilatory capacity along mid-expiration (V̇Ecap25−75), especially in vulnerable children with obesity who exhibit altered breathing mechanics. We estimated V̇Ecap25−75 pre- and post-albuterol treatment in 8−12yo children without (n = 28) and with (n = 46) obesity. A two-way ANOVA was performed to determine effects of an inhaled bronchodilator (pre-post) and obesity (group) on isoFEF25−75 and V̇Ecap25−75. There was no group by bronchodilator interaction or main group effect on outcome variables. However, a significant main effect of the bronchodilator was detected in spirometry parameters, including a substantial increase in isoFEF25−75 (17.1 ± 18.0 %) and only a slight (non-clinical) but significant increase in FEV1 (2.4 ± 4.3 %). V̇Ecap25−75 significantly increased with albuterol (+11.7 ± 10.6 L/min; +15.8 ± 13.9 %). These findings imply potentially important increases in ventilatory reserve with a bronchodilator in nonasthmatic children without and with obesity, which could potentially influence respiratory function at rest and during exercise.
Keywords
Bronchodilator; FEF 25-75; FEV 1; Forced expiratory flow; Responsiveness; Spirometry
Disciplines
Circulatory and Respiratory Physiology | Molecular and Cellular Neuroscience
Language
English
Repository Citation
Wilhite, D.,
Bhammar, D.,
Balmain, B.,
Martinez-Fernandez, T.,
Babb, T.
(2021).
Inhaled Albuterol Increases Estimated Ventilatory Capacity in Nonasthmatic Children Without and With Obesity.
Respiratory Physiology and Neurobiology, 285
1-7.
http://dx.doi.org/10.1016/j.resp.2020.103597
