Title
Association Between Motor Task Performance and Hippocampal Atrophy Across Cognitively Unimpaired, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease Individuals
Document Type
Article
Publication Date
2-15-2022
Publication Title
Journal of Alzheimer's Disease
Volume
85
Issue
4
First page number:
1411
Last page number:
1417
Abstract
Hippocampal atrophy is a widely used biomarker for Alzheimer's disease (AD), but the cost, time, and contraindications associated with magnetic resonance imaging (MRI) limit its use. Recent work has shown that a low-cost upper extremity motor task has potential in identifying AD risk. Fifty-four older adults (15 cognitively unimpaired, 24 amnestic mild cognitive impairment, and 15 AD) completed six motor task trials and a structural MRI. Several measures of motor task performance significantly predicted bilateral hippocampal volume, controlling for age, sex, education, and memory. Thus, this motor task may be an affordable, non-invasive screen for AD risk and progression.
Keywords
Alzheimer’s disease; hippocampus; mild cognitive impairment; psychomotor performance
Disciplines
Motor Control
Repository Citation
Schaefer, S. Y.,
Malek-Ahmadi, M.,
Hooyman, A.,
King, J. B.,
Duff, K.
(2022).
Association Between Motor Task Performance and Hippocampal Atrophy Across Cognitively Unimpaired, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease Individuals.
Journal of Alzheimer's Disease, 85(4),
1411-1417.
http://dx.doi.org/10.3233/JAD-210665