Title

Lower brain-derived neurotrophic factor levels associated with worsening fatigue in prostate cancer patients during repeated stress from radiation therapy.

Document Type

Article

Publication Date

3-27-2015

Publication Title

The World Journal of Biological Psychiatry

Volume

17

Issue

8

First page number:

608

Last page number:

614

Abstract

Fatigue during cancer treatment is associated with depression. Neurotrophic factors play a major role in depression and stress and might provide insight into mechanisms of fatigue. This study investigated the association between plasma concentrations of three neurotrophic factors (BDNF, brain-derived neurotrophic factor; GDNF, glial-derived neurotrophic factor; and SNAPIN, soluble N-ethylmaleimide sensitive fusion attachment receptor-associated protein) and initial fatigue intensification during external beam radiation therapy (EBRT) in euthymic non-metastatic prostate cancer men.

Keywords

fatigue; depression; brain-derived neurotrophic factor; radiation; prostate neoplasm

Disciplines

Nursing

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