Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression
Shank3, a post-synaptic density protein involved in N-methyl-d-aspartate (NMDA) receptor tethering and dendritic spine rearrangement, is implicated in the pathophysiology of bipolar disorder. We hypothesized that elevated baseline plasma Shank3 levels might predict antidepressant response to the NMDA receptor antagonist ketamine.
Ketamine; Bipolar depression; Shank3; MRI; PET
Niciu, M. J.,
Saligan, L. N.,
Nugent, A. C.,
Luckenbaugh, D. A.,
Zarate, Jr, C. A.
Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression.
Journal of Affective Disorders, 172