Title

Prenatal Glucocorticoid Treatment Completeness and Steroid Hormonal Levels as Related to Infant and Maternal Health

Document Type

Article

Publication Date

10-1-2020

Publication Title

Journal of Perinatal and Neonatal Nursing

Volume

34

Issue

4

First page number:

E32

Last page number:

E43

Abstract

This study was conducted to confirm the negative associations between testosterone and cortisol levels and health and developmental outcomes in very low-birth weight (VLBW) infants after controlling for prenatal glucocorticoid (GC) treatment. Seventy-four VLBW infant-mother pairs were recruited from a neonatal intensive care unit in the Southeastern United States. We divided the pairs into the complete (n = 58) and incomplete (n = 16) GC treatment groups. Data on infants and mothers were obtained at birth, 40 weeksʼ postmenstrual age, and 3 and 6 monthsʼ corrected age. Salivary testosterone and cortisol levels of the pairs were determined at 40 weeksʼ postmenstrual age using enzyme immunoassay. Log-linear and general linear mixed models showed that gestational age and birth weight were lower when testosterone was 1 pg/mL higher. When cortisol was 1 μg/dL higher, technology dependence at discharge was higher and motor development at 6 months was lower. Mothers with complete GC treatment had greater parity and gravida, more prenatal visits, and more medical complications. The study outcomes supported our hypothesis that steroid hormonal levels are more predictive of infant health and development than GC treatment completeness. Single dose of GC treatment might be just as effective as 2 doses, although further study with more subjects would be needed to confirm. As the associations with steroid hormonal levels lasted longer than the GC treatment associations, we recommend confirming the predictive effects of testosterone and cortisol levels after 6 months.

Keywords

VLBW preterm infants; Infant health and development; Maternal health; Postnatal steroid hormonal levels; Prenatal glucocorticoid treatment

Disciplines

Maternal and Child Health | Medicine and Health Sciences | Public Health

Language

English

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