Differences in the emergent coding properties of cortical and striatal ensembles
Document Type
Article
Publication Date
2014
Publication Title
Nature Meuroscience
Volume
17
First page number:
1100
Last page number:
1106
Abstract
The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. We recorded multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) simultaneously as rats performed different sequences of the same three actions. Sequence and lever decoding was markedly similar on a per-neuron basis in the two regions. At the ensemble level, sequence-specific representations in the DS appeared synchronously, but transiently, along with the representation of lever location, whereas these two streams of information appeared independently and asynchronously in the ACC. As a result, the ACC achieved superior ensemble decoding accuracy overall. Thus, the manner in which information was combined across neurons in an ensemble determined the functional separation of the ACC and DS on this task.
Disciplines
Medicine and Health Sciences | Mental and Social Health | Psychiatric and Mental Health
Language
English
Permissions
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Repository Citation
Ma, L.,
Hyman, J. M.,
Lindsay, A. J.,
Phillips, A. G.,
Seamans, J. K.
(2014).
Differences in the emergent coding properties of cortical and striatal ensembles.
Nature Meuroscience, 17
1100-1106.