Title

Mesolimbic Dopamine Reward System Hypersensitivity in Individuals With Psychopathic Traits

Document Type

Article

Publication Date

3-14-2010

Publication Title

Nature Neuroscience

Volume

13

Issue

4

First page number:

419

Last page number:

421

Abstract

Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [18F]fallypride positron emission tomography and blood oxygen level–dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy.

Keywords

Neuronal physiology; Pharmacology; Psychatric disorders

Disciplines

Medicine and Health Sciences | Psychiatry and Psychology | Psychological Phenomena and Processes

Language

English

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