Award Date

1-1-2006

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Health Sciences

First Committee Member

Philip Patton

Number of Pages

85

Abstract

Post-implant dosimetry analysis is a critical step in brachytherapy for identifying the quality of the implant based on seed localization in relation to the volume of the prostate. However, the accuracy of post-implant dosimetry analysis is dependent on accurate delineation of the prostate from surrounding tissue in post-implant CT images. Research has shown that adequately delineate the prostate from surrounding tissue in CT images is difficult, resulting in significant variation between the dose received by the prostate and the dose prescribed by the physician. This research compared prostate volumes delineated from pre-implant US, post-implant CT, and pre and post-implant MR images in order to develop a more reliable methodology to delineate the prostate. The results illustrated the superiority of MR imaging over CT imaging in delineation of the prostate thereby producing more individual and mean dosimetry values, D90 and V100, above their respective cut points of 140 Gy and 85%.

Keywords

Analysis; Brachytherapy; Dosimetry; Implant; MRI; Patient

Controlled Subject

Biophysics; Diagnostic imaging; Oncology

File Format

pdf

File Size

2355.2 KB

Degree Grantor

University of Nevada, Las Vegas

Language

English

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