Master of Science (MS)
First Committee Member
Number of Pages
Cisplatin is used clinically to treat various types of cancer. While effective in treating a variety of cancers it exhibits a wide range of side effects. Synthesis of novel cisplatin analogs, which exhibit increased cytotoxicity at lower doses, may alleviate some of the side effects; These analogs utilize 4,4'-bis(alkyl)-2,2'-bipyridine, a diimine, in place of the ammonia ligands present in cisplatin and the addition of substituents to the 4,4'-position as well as coordination to PtCl2 to yield a series of (4,4'-bis[alkyl]-2,2'-bipyridine) PtCl2 compounds. Modifications at the 4,4'-position occur by generating a benzylic dianion by way of lithium diisopropyl amide (LDA) and then substituting with the desired alkyl halide in a SN2 reaction. The different substitutions made in the 4,4' position are as follows: ethyl, propyl, n-butyl, methoxy and 3-methoxy-n-propyl. All of the coordination reactions have been done by ligand exchange where by PtCl2 exchanges from 1,5-cyclooctadiene (COD) to the bipyridine ligand.
Analogues; Bipyridine; Cisplatin; Containing; Derivatives
Organic chemistry; Pharmacology; Biochemistry
University of Nevada, Las Vegas
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Kabuloglu Karayusuf, Zeynep Gizem, "Cisplatin analogues containing 4,4'-bis[alkyl]-2,2'-bipyridine derivatives" (2007). UNLV Retrospective Theses & Dissertations. 2119.