Master of Science (MS)
First Committee Member
R. Keith Dupre
Second Committee Member
Penny S. Amy
Number of Pages
In order to determine whether heat shock proteins (HSP) can be used as indicators of environmental stress in the mammalian organism Peromyscus leucopus, three doses of each of two chemical stresses, cadmium chloride and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), were given intraperitoneally for 14 days. Proteins extracted from liver samples were compared by one-dimensional gel electrophoresis to liver protein samples from heat shocked and control animals. HSPs of 105,78, and 43 kDa were cadmium inducible. Non-heat shocked cadmium inducible proteins of 118, 55, and 47 kDa were seen. 2,4,5-T induced an increase in a 91 kDa protein. Low level cadmium induction of HSPs suggests useful applications in toxicological and general environmental tests.
Environmental; Heat; Indicators; Proteins; Shock; Stress
Zoology; Molecular biology; Physiology
University of Nevada, Las Vegas
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Castle, Arthur Louis, "Heat shock proteins as indicators of environmental stress" (1997). UNLV Retrospective Theses & Dissertations. 3.
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